在与急性冠状动脉综合征相关的动脉样硬化病变中增加组织内甲素免疫活性
A M Zeiher1, C Ihling, K Pistorius
1Department of Internal Medicine III, University of Freiburg, Germany.
Lancet (London, England)
|November 19, 1994
概括
在冠状动脉样硬化病变中发现了Endothelin-1,一种血管收缩剂,特别是在患有严重胸痛的患者中. 这表明endothelin-1可能会在急性冠状动脉综合征中导致冠状动脉静脉收缩.
科学领域:
- 心血管医学 心血管医学
- 病理学 病理学 病理学
背景情况:
- 急性冠状动脉综合征 (ACS) 涉及过度的冠状动脉血管收缩.
- 凝血素可以刺激内甲素-1的产生,这是一个强大的血管收缩剂.
研究的目的:
- 在冠状动脉样硬化病变中调查内甲素-1的存在和局部化.
- 探索内素-1在ACS.中出现的过度血管收缩中的潜在作用.
主要方法:
- 对30名患者的冠状动脉样进行了免疫组织化学检查.
- 普鲁士蓝色染色被用来检测斑块内出血的迹象.
主要成果:
- 在55%的稳定性胸痛病变中检测到类似内末素-1的免疫活性,在86%的缩性胸痛病变中检测到86%的缩性胸痛病变,在100%的静止性胸痛病变中检测到100%.
- 经常在有证据表明先前有斑块内出血的区域观察到对内衣林-1的免疫活性.
结论:
- 在冠状动脉样硬化病变中存在内末林-1.
- 组织内腺素-1可能在与急性冠状动脉综合征相关的夸张冠状动脉静脉收缩中发挥作用,特别是在存在内出血的情况下.
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