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相关概念视频

Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
Source And Potency Of Stem Cells01:27

Source And Potency Of Stem Cells

Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...

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相关实验视频

Updated: Jul 15, 2026

Isolation of Neural Stem/Progenitor Cells from the Periventricular Region of the Adult Rat and Human Spinal Cord
08:26

Isolation of Neural Stem/Progenitor Cells from the Periventricular Region of the Adult Rat and Human Spinal Cord

Published on: May 14, 2015

一个自我更新的多潜能干细胞在胚胎老鼠大脑皮层.

A A Davis1, S Temple

  • 1Department of Pharmacology, Albany Medical College, New York 12208.

Nature
|November 17, 1994
PubMed
概括

胚胎老鼠大脑中的多潜能干细胞可以产生各种各样的中枢神经系统细胞类型. 这些自我更新的干细胞对大脑发育至关重要,并且可能会产生其他原生细胞.

科学领域:

  • 神经科学是一个神经科学.
  • 发展生物学 发展生物学
  • 干细胞研究 干细胞研究

背景情况:

  • 在皮层心室区的神经外皮细胞对于产生多种细胞类型和维持生殖层至关重要.
  • 干细胞在维持生殖细胞群和在各种脊椎动物组织中产生分化的细胞方面发挥着至关重要的作用.

研究的目的:

  • 为了研究胚胎大脑皮层中的自我更新,多潜能干细胞的存在和特征.
  • 在体外测定单心室区细胞的分化潜力.

主要方法:

  • 从胚胎大鼠大脑皮层培养单心室区细胞.
  • 在克隆细胞中追踪单个细胞的发育命运.

主要成果:

  • 在大鼠胚胎大脑皮层中发现了自我更新的多潜能干细胞.
  • 证明了40%的这些干细胞可以产生神经元,星球细胞和寡细胞.
  • 发现干细胞衍生克隆构成了大约7%的皮质克隆,超过80%是小神经元或质克隆.

结论:

  • 多能干细胞存在于胚胎老鼠大脑皮层中.
  • 这些干细胞很可能是其他皮层前代细胞的祖先,其命运更受限制.

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The "Brain Milking" Method for the Isolation of Neural Stem Cells and Oligodendrocyte Progenitor Cells from Live Rats
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相关实验视频

Last Updated: Jul 15, 2026

Isolation of Neural Stem/Progenitor Cells from the Periventricular Region of the Adult Rat and Human Spinal Cord
08:26

Isolation of Neural Stem/Progenitor Cells from the Periventricular Region of the Adult Rat and Human Spinal Cord

Published on: May 14, 2015

Live Imaging of Primary Cerebral Cortex Cells Using a 2D Culture System
10:12

Live Imaging of Primary Cerebral Cortex Cells Using a 2D Culture System

Published on: August 9, 2017

The "Brain Milking" Method for the Isolation of Neural Stem Cells and Oligodendrocyte Progenitor Cells from Live Rats
06:52

The "Brain Milking" Method for the Isolation of Neural Stem Cells and Oligodendrocyte Progenitor Cells from Live Rats

Published on: February 9, 2024

  • 了解这些干细胞是理解皮层发育和祖细胞层次的关键.