随机试验单剂量西普罗夫洛克萨用于旅行者腹
I Salam1, P Katelaris, S Leigh-Smith
1Department of Medicine and Gastroenterology, Queen Elizabeth Military Hospital, Woolwich, London, UK.
Lancet (London, England)
|December 3, 1994
概括
一次500毫克的西普罗夫洛克萨剂量有效治疗旅行者腹. 这种抗生素在部署到伯利兹的英国军队中显著减少了腹的持续时间和严重程度,提供了一个具有成本效益和合规的治疗选择.
科学领域:
- 传染性疾病 传染性疾病
- 热带医学 热带医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 旅行者腹是访问发展中国家的个人常见的疾病.
- 旅行者急性腹的经验性治疗选择对于保持健康和作战准备至关重要.
研究的目的:
- 为了比较单次500毫克剂量西普罗夫洛克萨与安慰剂治疗急性旅行者腹的疗效.
- 为了评估普洛素对腹症状的持续时间和严重性的影响.
主要方法:
- 一个随机的,安慰剂控制的试验是在伯利兹的英国军队在部署后的前8周内进行的.
- 在发病后24小时内出现腹的参与者接受了500毫克西普罗夫洛克萨或安慰剂.
- 症状严重程度和便一致性被记录了72小时或直到恢复.
主要成果:
- 齐普罗夫洛克萨显著减少了腹的平均持续时间 (从50.4-53.5小时降至20.9-24.8小时,p < 0.0001).
- 液体便的数量在西普罗夫洛克萨辛组显著下降 (平均值为5.0对11.4,p < 0.0001).
- 与安慰剂相比,24小时,48小时和72小时的累积康复率在西普罗夫洛克萨 (64%,82%,93%) 和安慰剂 (11%,42%,79%) 中显著高.
结论:
- 一次500毫克的西普罗夫洛克萨剂量是急性旅行者腹的有效实证治疗方法.
- 这种疗法提供了一个合规,具有成本效益和时间效率的治疗策略.
- 普洛素显然可以减少急性腹的旅行者疾病的持续时间和严重程度.
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