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Updated: Jul 6, 2026

A Technique for Serial Collection of Cerebrospinal Fluid from the Cisterna Magna in Mouse
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A Technique for Serial Collection of Cerebrospinal Fluid from the Cisterna Magna in Mouse

Published on: November 10, 2008

在对改性β-粉样前体蛋白基因同卵性小鼠的行为和解剖缺陷

U Müller1, N Cristina, Z W Li

  • 1Institut für Molekularbiologie I, Universität Zürich, Switzerland.

Cell
|December 2, 1994
PubMed
概括

在小鼠中破坏β-粉样蛋白前体蛋白 (β APP) 基因,意外产生了改变的RNA和蛋白质,导致严重的学习和行为缺陷.

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Lethal Alleles02:41

Lethal Alleles

Agouti: A Lethal Allele
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...