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Updated: May 4, 2026

Inducible and Reversible Dominant-negative DN Protein Inhibition
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Id1基因的构成性表达会影响小鼠B细胞的发育

X H Sun1

  • 1Department of Cell Biology, Kaplan Comprehensive Cancer Center New York University Medical Center, New York 10016.

Cell
|December 2, 1994
PubMed
概括

构成性表达Id1通过抑制基本螺旋环螺旋 (bHLH) 转录因子,损害B细胞发育. 这导致转基因小鼠的B细胞数量减少和免疫球蛋白基因重组受损.

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Study of Dendritic Cell Development by Short Hairpin RNA-Mediated Gene Knockdown in a Hematopoietic Stem and Progenitor Cell Line In vitro06:12

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Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
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