最初以摘要形式呈现的结果的完整出版. 一个元分析
R W Scherer1, K Dickersin, P Langenberg
1Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore 21201.
JAMA
|July 13, 1994
概括
大约一半的随机临床试验摘要,特别是在眼科,在两年内完全发表. 发表率可能与重大发现和更大的样本大小相关.
科学领域:
- 眼科医生 眼科 眼科
- 医学研究 医学研究
- 出版物 科学科学 出版物
背景情况:
- 许多研究成果最初以摘要形式在科学会议上提出.
- 这些摘要的完整出版率在各学科之间有所不同.
- 了解影响完整出版的因素对于科学传播至关重要.
研究的目的:
- 估计眼科随机临床试验摘要在1988-1989年的完整出版率.
- 综合与类似研究的数据,以确定总体抽象出版率.
- 为了确定与完整出版相关的研究特征.
主要方法:
- 从关键的国家会议 (1988-1989年) 中审查了眼科摘要.
- 从文献搜索 (MEDLINE) 和内部数据中确定并包括了类似的研究.
- 在至少24个月的时间里对摘要进行了跟踪,以确保完全发表.
主要成果:
- 66%的眼科摘要全文发表.
- 来自11项研究的综合数据显示,摘要的整体完整出版率为51%.
- 全面发表显示,与"显著"结果和更大的样本大小的联系很弱.
结论:
- 大约一半的研究摘要最终以全篇文章的形式发表.
- 完全发表通常发生在最初的摘要介绍后的两年内.
- 显著的结果和更大的研究规模可能会增加完全发表的可能性.
相关概念视频
01:05Long-term Depression
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
01:23Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...