受体氨酸/氨酸激酶参与控制Drosophila的身体模式,通过十足的脑
D Nellen1, M Affolter, K Basler
1Zoologisches Institut Universität Zürich, Switzerland.
Cell
|July 29, 1994
概括
两个新的Drosophila基因,萨克斯 (sax) 和厚静脉 (tkv),编码I型TGF-β受体. 它们的活动对于脑衰 (dpp) 信号传递至关重要,在发育过程中影响细胞命运规范.
科学领域:
- 发育生物学 发展生物学
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
背景情况:
- 转化生长因子-β (TGF-β) 超级家族蛋白质是细胞过程的关键调节者.
- 这些信号分子与具有酶域的特定的I型和II型膜受体相互作用.
研究的目的:
- 为了识别和描述Drosophila.I型受体家族的新成员.
- 为了研究这些受体在十角 (dpp) 信号通路中的作用.
主要方法:
- 果虫突变的遗传分析.
- 基因淘汰的表型特征. 基因淘汰.
- 对TGF-β超级家族信号通路的分析.
主要成果:
- 两个Drosophila基因,萨克斯 (sax) 和厚静脉 (tkv),被确定为编码I型TGF-β受体.
- 萨克斯和tkv的突变导致表型反映了十头 (dpp) 功能丧失突变的表型.
- 萨克斯和tkv突变导致分别部分和完全丧失dpp活动.
结论:
- 萨克斯和厚静脉是Drosophila中十角的信号传递的必不可少的I型受体.
- 萨克斯和tkv受体的组合作用可能会调解不同的细胞命运规范,以应对不同度的脱.
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