身体修养降低了子中诺阿皮内林诱导的血管收缩. 北上腺素引起的内皮衍生的放松因子的可能作用
1Department of Physiology, Medical College, National Cheng-Kung University, Tainan, Taiwan, Republic of China.
Circulation
|August 1, 1994
概括
在子中,耐力运动训练降低了对北上腺素 (NE) 的血管收缩反应,并增强了NE刺激的内皮衍生放松因子 (EDRF) 释放,表明血管功能得到改善.
科学领域:
- 心血管生理学心血管生理学
- 运动科学 运动科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 众所周知,体力活动可以降低同情的声音,并有益于人类的健康.
- 慢性炼对上腺体血管收缩剂 (如上腺素 (NE)) 的血管反应的影响尚不清楚.
- 这项研究研究了耐力运动对NE诱导的血管收缩及其潜在机制对子的影响.
研究的目的:
- 为了确定耐力运动训练是否会改变健康子对北上腺素的血管收缩反应.
- 探索潜在的机制,特别是内皮衍生的放松因子 (EDRF) 在调解这些变化的作用.
- 研究特定上腺素受体在观察到的血管反应中的参与.
主要方法:
- 子接受了为期8周的跑步机训练计划.
- 隔离胸前动脉以测量血管张力和NE诱导的血管收缩.
- 血管反应被评估为内皮完好无损,预处理 (L-NNA) 或剥离的大动脉细分.
- 评估EDRF释放使用血红蛋白,一个EDRF清理器.
- 还研究了对特定上腺激素激动剂 (烯,克洛尼丁) 的反应.
主要成果:
- 运动训练提高了胸前动脉的[NE]ED50,表明对NE的敏感性降低.
- 通过血红蛋白或L-NNA评估的NE刺激EDRF释放在训练后的子中明显高于对照组.
- 烯和克罗尼丁都诱导了血管松,L-NNA减弱了血管松,这表明EDRF参与.
- 上腺素刺激EDRF释放,可能通过内皮细胞上的α1和α2上腺体受体.
结论:
- 耐力运动训练似乎可以降低子胸前动脉对诺尔上腺素的血管收缩反应.
- 运动训练可以增强北上腺素刺激的EDRF释放,有助于改变血管反应.
- 这些发现表明,运动可以改善血管健康并调节同情度的机制.
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