在伦敦动物园的黑猩猩中爆发了B型肝炎疫情
Lancet (London, England)
|September 23, 1978
概括
在伦敦动物园的9只黑猩猩中,在5只中发现了乙型肝炎病毒 (HBV),并有可能通过围产期传播. 工作人员安全措施防止了人类的HBV感染.
科学领域:
- 兽医病毒学 兽医病毒学
- 灵长类健康 灵长类健康
- 乙型肝炎研究 乙型肝炎研究
背景情况:
- 乙型肝炎病毒 (HBV) 构成动物感染的风险.
- 了解非人类灵长类动物中的HBV存储库对于公共卫生至关重要.
研究的目的:
- 为了调查伦敦动物园的黑猩猩的乙型肝炎病毒携带情况.
- 评估潜在的传播途径和动物园工作人员的风险.
主要方法:
- 对黑猩猩和其他灵长类动物的HBV表面抗原和抗体进行血清检测.
- 对动物园工作人员进行血清转换的监视.
- 使用干扰素和利巴维林进行治疗干预.
主要成果:
- 在九只黑猩猩中,有五只是高位数HBV携带者;四只有抗体.
- 在大猩猩,猩猩或吉本身上没有检测到HBV表面抗原.
- 在动物园出生的三只携带者黑猩猩中怀疑围产传染.
- 在两年内,在使用安全协议和免疫球蛋白预防时,没有发生人员血清转化.
- 抗病毒治疗在携带者黑猩猩中只显示了暂时的效果.
结论:
- 黑猩猩可以作为乙型肝炎病毒的储存库.
- 严格的安全措施有效地保护动物园工作人员免受HBV感染.
- 目前的抗病毒治疗不能治愈黑猩猩慢性HBV携带.
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