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Updated: Jun 20, 2026

An In Vitro Model for the Study of Cellular Pathophysiology in Globoid Cell Leukodystrophy
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缺少MHCII类分子会减少中枢神经系统脱髓化,微质/巨细胞透,以及在小鼠球状细胞白血病中抽

G K Matsushima1, M Taniike, L H Glimcher

  • 1Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill 27599.

Cell
|August 26, 1994
PubMed
概括

全球细胞白血病 (GLD) 是一种严重的遗传性脱髓化疾病. 在Twitcher小鼠模型中减少免疫反应抗原 (Ia) 表达显著降低了疾病严重程度和神经症状.

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相关概念视频

Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
Antigen Processing Pathways01:31

Antigen Processing Pathways

MHC molecules are key players in the immune response, enabling T cells to recognize and respond to specific antigens. They are present on the surface of all nucleated cells in the body and are instrumental in presenting antigens to T cells and activating them. T cells recognize the MHC-antigen complex and initiate an immune response. MHC class I and MHC class II are two main types of MHC molecules, each associated with a distinct antigen processing pathway.
MHC Class I: Presenting Endogenous...