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Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding
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在患有内分泌功能增加和丧失的患者中,Gsα的快速GDP释放

T Iiri1, P Herzmark, J M Nakamoto

  • 1Department of Pharmacology, University of California, San Francisco 94143-0450.

Nature
|September 8, 1994
PubMed
概括

一个新的Gsα子单元突变通过构成性地激活腺酸环酶,导致测试毒性和类型Ia的伪副类甲状腺症. 这种突变导致激素独立的激素分泌和在体温下Gs活性受损.

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