曲背和双形形态原体之间的协同作用是需要在Drosophila的前面模式
M Simpson-Brose1, J Treisman, C Desplan
1Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021-6399.
Cell
|September 9, 1994
概括
驼背 (hb) 对于双 (bcd) 是必不可少的,以塑造Drosophila胚胎的模式. 如果没有母体和胚胎的hb,bcd目标基因就会失效,破坏胚胎的极性和发育.
科学领域:
- 发育生物学是发展生物学.
- 遗传学 是一个遗传学.
- 分子生物学分子生物学
背景情况:
- 在Drosophila胚胎中,前面的模式依赖于局部缺口基因表达.
- 母性形态双体 (bcd) 梯度控制了基因表达的差距.
- 驼背 (hb) 是另一种孕产妇因素,在某些地区可以替代BCD.
研究的目的:
- 为了调查背 (hb) 在双体 (bcd) 功能中的作用,在Drosophila胚胎发生过程中.
- 要确定hb是否需要bcd来执行其模式功能.
主要方法:
- 对Drosophila胚胎缺乏母体和胚胎背 (hb) 的分析.
- 检查已知的双体 (bcd) 基因的表达模式.
- 研究HB和BCD对HB和Head Gap基因的协同激活.
主要成果:
- 缺乏母体和胚胎HB的胚胎表现出被破坏的极性.
- 所有已知的bcd标基因在hb缺陷胚胎中表达不正确.
- 对于正确的HB和Head Gap基因表达,HB和BCD的协同激活是必要的.
结论:
- 凸鱼 (hb) 对于双鱼 (bcd) 来说是不可或缺的,以满足其所有图案功能.
- bcd和hb的联合活性,而不是单独的bcd,产生了胚胎极性的形态遗传梯度.
- 比科伊德 (bcd) 可能是Drosophila最近进化的基因,逐渐接管其他物种中发现的母性HB的功能.
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