在正常体重的女性中,胆结石的解释是:肠道过渡缓慢
K W Heaton1, P M Emmett, C L Symes
1University Department of Medicine, Bristol Royal Infirmary, UK.
Lancet (London, England)
|January 2, 1993
概括
正常体重的女性患有胆结石往往会经历肠道过渡缓慢. 这项研究发现,与对照组相比,这些女性的全肠传输时间 (WGTT) 显著更长,这表明胆结石形成的潜在原因.
科学领域:
- 胃肠病学 胃肠病学
- 胆管系统研究 胆管系统研究
- 代谢和内分泌系统疾病
背景情况:
- 肥胖是胆结石的主要危险因素,但其在正常体重女性中的作用尚不清楚.
- 之前的生化研究将慢慢的肠道过渡与胆汁的前体 - - 胆结石的前体 - - 联系起来.
- 在非肥胖个体中胆结石的病因需要进一步研究.
研究的目的:
- 为了测试一个假设,正常体重的女性患有胆结石,表现出异常缓慢的肠道通道.
- 在没有肥胖的女性中识别胆结石的潜在原因.
主要方法:
- 在英国布里斯托尔对1058名女性 (25-69岁) 进行人口调查,使用胆囊声学检测胆结石.
- 测量全肠传输时间 (WGTT) 在15名正常体重的女性,胆结石和年龄匹配的对照.
- 直接测量或从排便记录中计算的WGTT;便输出也得到量化.
主要成果:
- 与对照组 (63小时) 相比,正常体重的患有胆结石的女性 (82小时) 观察到明显更长的平均WGTT.
- 患有胆结石的女性的便量明显低 (74g/24h) 比对照组 (141g/24h).
- 在BMI,腰比,平衡,甘油三水平或酒精摄入量方面没有发现显著差异.
结论:
- 患有胆结石的正常体重女性的特点是肠道过渡缓慢.
- 缓慢的肠道过渡是这种人口中的胆结石形成的潜在因素.
- 对运动障碍的进一步研究可能会揭示非肥胖个体的胆结石病原性.
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