在性结肠炎中增加氧化合成
S J Middleton1, M Shorthouse, J O Hunter
1Department of Gastroenterology, Addenbrooke's Hospital, Cambridge, UK.
Lancet (London, England)
|February 20, 1993
概括
在活跃的性结肠炎中观察到氧化物 (NO) 生产增加,由较高的素水平表明. 这表明NO可能在疾病中发挥作用.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 生物化学 生物化学
背景情况:
- 氧化 (NO) 由NO合成酶合成,释放素.
- 性结肠炎 (UC) 是一种影响结肠的慢性炎症性肠病.
研究的目的:
- 调查氧化 (NO) 生物合成在活性性结肠炎 (UC) 中的作用.
- 为了确定UC组织中NO的产生是否增加.
主要方法:
- 在从患有活跃UC,静止UC和正常组织学患者的直肠活检样本中测量了鲁林度.
- 用NG-单甲基-L-氨酸 (L-NMMA) 化UC活检样本,以评估其对素生产的影响.
主要成果:
- 与静止UC或正常组织学相比,在活跃UC活检中,citrulline度显著更高.
- 通过L-NMMA抑制NO合成酶减少了UC活检样本中的氨酸生产.
结论:
- 粘膜NO生物合成在活性性结肠炎中增加.
- 增加的NO生产可能会导致性结肠炎的发病.
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