鉴定类似于Plasmodium vivax的人类疟疾寄生虫
S H Qari1, Y P Shi, I F Goldman
1Malaria Branch, National Center for Infectious Disease, Centers for Disease Control, Atlanta, Georgia 30341.
Lancet (London, England)
|March 27, 1993
概括
一种新的人类疟疾寄生虫已被确定,与已知的物种不同. 它的环球体蛋白与子疟疾寄生虫非常相似,这表明潜在的进化联系和疟疾控制的新目标.
科学领域:
- * 分子寄生虫学 * 分子寄生虫学
- * 灵长类疟疾研究
- * 进化生物学 进化生物学
背景情况:
- *四种Plasmodium种类导致人类疟疾,与灵长类Plasmodia有潜在的进化联系.
- *分子生物学已经揭示了Plasmodium vivax内部的变异,这表明了进一步的复杂性.
- * 某些人类和子疟疾寄生虫之间存在形态相似之处.
研究的目的:
- * 为了识别和描述一种新的人类疟疾寄生虫.
- * 为了研究人类和灵长类疟疾寄生虫之间的进化关系.
- * 基于寄生虫蛋白质变异来探索潜在的诊断和治疗点.
主要方法:
- * 用显微镜识别疟疾寄生虫.
- * 基于Oligonucleotide的Plasmodium物种的类型.
- * 环状体 (CS) 蛋白质的测序和分析.
- *使用多克隆抗血清和合成的血清分析.
- * 18S核糖体DNA序列的比较.
主要成果:
- * 一种人类疟疾寄生虫,在形态上类似于Plasmodium vivax,被鉴定为具有独特的环状虫 (CS) 蛋白质.
- * 这种新型寄生虫的CS蛋白与子寄生虫Plasmodium simiovale的CS蛋白相同.
- *来自特有地区的人类血清中的特定抗体与新型寄生虫的CS蛋白的反应.
- * 分子和血清学数据表明,这种新的寄生虫与已知的人类疟疾物种 (P. falciparum,P. malariae,P. vivax,P. ovale) 是不同的.
结论:
- * 发现了一种新的人类疟疾寄生虫物种,暂时称为"P.vivax-like".
- * 这种寄生虫与子寄生虫P. simiovale共享一种独特的环状寄生虫蛋白质,这表明一种动物性链接或共同的祖先.
- *这些发现需要重新评估疟疾寄生虫分类和诊断,这可能会影响疟疾控制策略.
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