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相关概念视频

Carbon Skeletons01:12

Carbon Skeletons

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Life on Earth is carbon-based, as all macromolecules that make up living organisms contain carbon atoms. All organic compounds have a carbon backbone. Each carbon atom is tetravalent and can bond with four other atoms, making it an extraordinarily flexible component of biological molecules. Because carbon’s valence electrons are stable, it rarely becomes an ion. As the carbon chain increases in length, structural modifications such as ring structures, double bonds, and branching side...
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Gross Anatomy of Bone01:17

Gross Anatomy of Bone

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The two main features of a long bone are the diaphysis and the epiphysis.
The diaphysis is the tubular shaft that runs between the proximal and distal ends of the bone. The walls of the diaphysis are composed of dense and hard compact bone made of numerous osteons — the functional unit of the compact bone. The hollow region in the diaphysis is called the medullary cavity, which harbors the bone marrow. In infants and children, this marrow cavity is filled with red marrow, whereas in...
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Compact Bone01:27

Compact Bone

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Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
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Virtual Work for a System of Connected Rigid Bodies01:06

Virtual Work for a System of Connected Rigid Bodies

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Virtual work is a powerful method used to solve problems involving several connected rigid bodies. When the system is in equilibrium, virtual work is zero. This allows the calculation of the resulting forces when a system undergoes a virtual displacement. When attempting to analyze such a system, first, use a free-body diagram, where an independent coordinate represents the configuration of the links, and mark its deflected position resulting from the positive virtual displacement.
Next,...
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Spinal Cord: Cross-sectional Anatomy01:16

Spinal Cord: Cross-sectional Anatomy

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The cross-sectional anatomy of the spinal cord offers a detailed view of its complex structure and function within the central nervous system. At the core of the spinal cord lies the gray matter, characterized by its butterfly or "H"-shaped appearance in cross-section. This central region is enveloped by white matter, with the overall structure divided into symmetrical halves by the dorsal median sulcus and the ventral median fissure.
Gray Matter and its Components
Central to the gray matter is...
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Steel Manufacturing01:26

Steel Manufacturing

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Steel manufacturing is a multi-stage process that begins by smelting iron ore into cast iron in a blast furnace. This initial stage involves layering iron ore with coke, a type of fuel, and crushed limestone within the furnace. The coke is ignited with a high volume of air, leading to the creation of carbon monoxide, which acts to reduce the iron ore to pure iron.
During this smelting process, limestone plays a crucial role by forming slag. Slag captures impurities within the molten iron, such...
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相关实验视频

Updated: May 4, 2026

Operation of the Collaborative Composite Manufacturing CCM System
10:09

Operation of the Collaborative Composite Manufacturing CCM System

Published on: October 1, 2019

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复制工厂连接到核骨架的可视化图.

P Hozák1, A B Hassan, D A Jackson

  • 1Sir William Dunn School of Pathology, University of Oxford, England.

Cell
|April 23, 1993
PubMed
概括

DNA复制发生在与细胞骨架相连的离散部位或"工厂"中. 新合成的DNA最初出现在这些工厂中,然后扩散到周围的染色质中.

科学领域:

  • 细胞生物学 细胞生物学
  • 分子生物学分子生物学
  • 遗传学 是一个遗传学.

背景情况:

  • DNA复制对于细胞分裂至关重要.
  • 人们还没有完全理解DNA复制站点的空间组织.

研究的目的:

  • 为了可视化和描述核内DNA合成的物理场所.
  • 研究这些地点DNA复制的动态.

主要方法:

  • 赫拉细胞被封装在阿加罗斯微粒中.
  • 用生物-11-dUTP标记了DNA合成部位,并进行了免疫标记.
  • 光和电子显微镜被用来检查核结构.
  • 染色质被部分删除以可视化底层结构.

主要成果:

  • 每个核中观察到大约150个DNA合成的焦点点.
  • 这些部位含有DNA聚合酶α和增殖细胞核抗原.
  • 电子显微镜揭示了与核骨架相连的离散卵状体.
  • 生物素的结合最初发生在这些卵状体内,然后扩散到染色体中.

结论:

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  • DNA复制发生在固定聚合工厂中,该工厂与核骨架相连.
  • 随着DNA模板在这些静止工厂中移动,复制过程继续进行.