人类帕沃病毒感染在同卵性状细胞疾病中的感染
G R Serjeant1, B E Serjeant, P W Thomas
1British Medical Research Council Laboratories (Jamaica), University of the West Indies, Kingston.
Lancet (London, England)
|May 15, 1993
概括
人类帕沃病毒B19感染在患有状细胞病 (SS) 和正常血红蛋白 (AA) 基因型的儿童中流行. B19在SS疾病中引起大多数无形成性危机,但并非所有感染都会导致无形成性.
科学领域:
- 病毒学 病毒学
- 血液学 血液学 血液学
- 流行病学 流行病学
背景情况:
- 状细胞病 (SS) 是一种遗传性血液疾病.
- 人类帕沃病毒B19 (B19) 是一种常见的病毒.
- 无形性危机是状细胞病的严重并发症.
研究的目的:
- 在患有状细胞疾病的儿童中调查人类parvovirus B19感染的流行病学.
- 确定B19感染和状细胞疾病中的无塑性危机之间的关系.
- 评估状细胞病患者对B19感染的长期免疫反应.
主要方法:
- 一项队列研究跟踪了308名患有同卵性状细胞疾病的儿童和239名出生时具有正常血红蛋白基因型的对照.
- 每年收集血清样本以确定B19感染.
- 监测了无质性危机和血液学变化.
主要成果:
- 在SS和AA儿童中,B19感染的发病率和频率没有差异;在15岁时,每组约有40%的儿童产生了特定的IgG.
- B19感染遵循了流行病模式,在SS患者中占据了所有91次观察到的无形性危机.
- 在SS患者中,至少20%的B19感染并没有导致无形成性质,并且没有患者经历过复发性无形成性质.
结论:
- 人类帕沃病毒B19感染是状细胞疾病中无形性危机的主要原因.
- 虽然B19感染与无形性危机有关,但并非所有感染都会导致这种并发症.
- 有效的B19疫苗可以显著帮助管理状细胞疾病.
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