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在动物疟疾感染中TH1和TH2细胞的作用
A W Taylor-Robinson1, R S Phillips, A Severn
1Wellcome Laboratories for Experimental Parasitology, University of Glasgow, United Kingdom.
Science (New York, N.Y.)
|June 25, 1993
概括
TH1和TH2辅助T细胞 (CD4+T细胞) 均能对疟疾进行保护. TH1细胞使用氧化,而TH2细胞促进免疫的抗体产生.
科学领域:
- 免疫学 免疫学 免疫学
- 寄生虫学的寄生虫学
- 传染性疾病 传染性疾病
背景情况:
- CD4+ T 细胞对于免疫力对抗血液阶段疟疾至关重要.
- 通过CD4+T细胞给予保护的精确机制仍然不完全理解.
研究的目的:
- 阐明疟疾中CD4+T细胞TH1和TH2子集所使用的独特保护机制.
- 为特定的T辅助细胞子集在抗疟疾免疫中的作用提供直接证据.
主要方法:
- 将克隆的T细胞系通过收养转移到接受者小鼠中.
- 在小鼠中感染了Plasmodium chabaudi chabaudi.
- 保护机制的分析,包括氧化的产生和抗体反应.
主要成果:
- TH1和TH2 CD4+ T 细胞子集都表现出对小鼠的Plasmodium chabaudi chabaudi感染的保护能力.
- TH1细胞介导的保护依赖于氧化.
- 通过TH2细胞介导的保护涉及到增强和加速特定免疫球蛋白G1 (IgG1) 抗体的产生.
结论:
- 不同的CD4+T辅助细胞子集 (TH1和TH2) 通过不同的作用因子通路介导抗疟疾的保护.
- 氧化是TH1细胞保护的关键媒介.
- 抗体增强,特别是IgG1,对于TH2细胞介导的抗疟疾免疫是至关重要的.
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