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Updated: Jul 20, 2026

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化学同源盒基因E2A-PBX1诱导转基因小鼠的增殖,亡和恶性淋巴瘤

D A Dedera1, E K Waller, D P LeBrun

  • 1Department of Pathology, Stanford University School of Medicine, California 94305.

Cell
|September 10, 1993
PubMed
概括

E2A-PBX1融合基因在小鼠中导致淋巴瘤的快速发展. 这种瘤基因矛盾地驱动淋巴细胞增殖和编程细胞死亡,导致恶性瘤.

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Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...