灵长类视网膜中的"蓝色"对手通路起源于一个独特的双层化节细胞类型
Nature
|February 24, 1994
概括
研究人员确定了一种独特的非矮人视网膜质细胞,小的双层细胞,作为该细胞的基因.
科学领域:
- 神经科学是一个神经科学.
- 视觉科学 视觉科学 视觉科学
- 视网膜生理学视网膜生理学
背景情况:
- 人类和旧世界子的色彩视觉依赖于三个型 (S,M,L).
- 圆信号由视网膜的质细胞处理,形成对手通道 (红绿色和蓝黄色).
- 颜色对立的神经通路,特别是蓝黄色,仍然不清楚,以前认为矮细胞传输所有对手信号.
研究的目的:
- 为了确定负责在蓝黄色对手通路中传输短波长 (S) 信号的特定视网膜质细胞类型.
- 阐明蓝黄色颜色对立的解剖学和生理学的基础.
主要方法:
- 从视网膜质细胞的生理记录.
- 对已识别的质细胞类型进行形态分析.
- 从形光受体到质细胞的神经通路的追踪.
主要成果:
- 一种独特的非矮人质细胞类型,小双层细胞,被确定为"蓝色"细胞.
- 这种细胞类型从S体接收激发性输入.
- 证明了S信号传输到大脑的解剖学上独特的途径.
结论:
- 小双层细胞是S信号在蓝黄色对手通路中的主要通道.
- 这一发现挑战了以前关于矮细胞传输所有对手信号的假设.
- 这个小双层细胞的形态表明了新的视网膜电路用于蓝黄色颜色处理.
相关概念视频
The Retina
The retina is a layer of nervous tissue at the back of the eye that transduces light into neural signals. This process, called phototransduction, is carried out by rod and cone photoreceptor cells in the back of the retina.
Vision
Vision is the result of light being detected and transduced into neural signals by the retina of the eye. This information is then further analyzed and interpreted by the brain. First, light enters the front of the eye and is focused by the cornea and lens onto the retina—a thin sheet of neural tissue lining the back of the eye. Because of refraction through the convex lens of the eye, images are projected onto the retina upside-down and reversed.
Channel Rhodopsins
Most organisms use photoreceptors to sense and respond to light. Examples of photoreceptors include bacteriorhodopsins and bacteriophytochromes in some bacteria, phytochromes in plants, and rhodopsins in the photoreceptor cells of the vertebral retina. The light-sensitive property of these receptors is because of the bound chromophores, such as bilin in the phytochromes and retinal in the rhodopsins.
Rhodopsins belong to the family of cell surface proteins called G-protein coupled receptors,...
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Anatomy of the Eyeball
The eye is a spherical, hollow structure composed of three tissue layers. The outer layer — the fibrous tunic, comprises the sclera — a white structure — and the cornea, which is transparent. The sclera encompasses some of the ocular surface, most of which is not visible. However, the 'white of the eye' is distinctively visible in humans compared to other species. The cornea, a clear covering at the front of the eye, enables light penetration. The eye's middle layer, the vascular tunic,...
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At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category, whereas...
Color Vision
Color perception begins in the retina, the light-sensitive layer at the back of the eye. Two main theories explain how colors are seen: the trichromatic theory and the opponent-process theory. The trichromatic theory, proposed by Thomas Young in 1802 and extended by Hermann von Helmholtz in 1852, suggests that color vision is based on three types of cone receptors in the retina. These cones are sensitive to different but overlapping ranges of wavelengths corresponding to red, blue, and green.


