相关实验视频
Updated: Aug 7, 2026
09:40
Detection of True IgE-expressing Mouse B Lineage Cells
Published on: December 1, 2014
埃索诺菲尔细胞上的高亲和性IgE受体参与了对寄生虫的防御
A S Gounni1, B Lamkhioued, K Ochiai
1Centre d'Immunologie et de Biologie Parasitaire, Unite Mixte INSERM U167-CNRS624, Institut Pasteur, Lille, France.
Nature
|January 13, 1994
概括
乙氨基和免疫球蛋白E (IgE) 对抗寄生虫感染. 埃索诺菲尔细胞上的高亲和性IgE受体 (Fc epsilon RI) 对于对抗Schistosoma mansoni寄生虫至关重要.
科学领域:
- 免疫学 免疫学 免疫学
- 寄生虫学的寄生虫学
- 细胞生物学 细胞生物学
背景情况:
- 寄生虫感染经常与埃索因菲利亚和免疫球蛋白E (IgE) 水平升高相关.
- 假设埃索诺菲尔和IgE在对寄生虫的免疫反应中合作.
- 之前的研究表明,低亲和性IgE受体 (Fc epsilon RII/CD23) 参与了氨基细胞的激活.
研究的目的:
- 为了研究高亲和性IgE受体 (Fc epsilon RI) 的存在和作用.
- 为了确定Fc epsilon RI对乙酸蛋白的作用是否有助于对寄生虫感染的免疫防御,特别是 Schistosoma mansoni.
主要方法:
- 研究了Fc epsilon RI在高氨酸性患者的氨酸蛋白上的表达.
- 评估了Fc epsilon RI在氨基酸脱粒化中的作用.
- 在实验室中评估了Fc epsilon RI表达的乙酸在对Schistosoma mansoni幼虫的细胞毒性中的参与.
主要成果:
- Fc epsilon RI是表达在高氨酸性患者的氨酸上.
- 埃索诺菲尔体上的Fc epsilon RI表达与埃索诺菲尔体的脱粒化有关.
- 表达Fc epsilon RI的埃索诺菲尔体对Schistosoma mansoni幼虫表现出细胞毒性.
结论:
- 高亲和性IgE受体 (Fc epsilon RI) 存在于乙酸细胞上,在它们的功能中起着重要作用.
- Fc epsilon RI在氨基酸上有助于对寄生虫感染的免疫防御,例如Schistosoma mansoni.
- 这一发现突出了免疫反应中关键的机制,涉及氨基和IgE.
相关概念视频
01:10Antibody Structure
Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
00:42Cross-reactivity
Overview
02:06Allergic Reactions
Overview
01:15Transcytosis of IgG
Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
01:22Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal
Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
01:28Amebiasis
Entamoeba histolytica, a protozoan parasite, is responsible for intestinal and extraintestinal amebiasis. Though a significant proportion of infections remain asymptomatic, approximately 50 million individuals annually are estimated to present with clinical disease, resulting in up to 100,000 deaths globally. The disease burden is disproportionately high in regions with lower socioeconomic status, such as parts of India, Africa, Mexico, and Latin America.Etiology and TransmissionThe infective...