体重和死亡率. 对中年男性进行了27年的随访
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Updated: Aug 4, 2026

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Assessment of Child Anthropometry in a Large Epidemiologic Study
Published on: February 2, 2017
I M Lee1, J E Manson, C H Hennekens
1Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115.
JAMA
|December 15, 1993
概括
这项研究发现,男性的体重和全因死亡率之间存在直接关系. 在体重明显低于美国平均水平的男性中,死亡率最低,而较瘦个体没有过度风险.
科学领域:
- 流行病学 流行病学
- 公共卫生 公共卫生
- 生物统计学 生物统计学
背景情况:
- 体重与死亡率之间的关系是复杂的,受到各种因素的影响.
- 之前的研究表明,身体质量指数 (BMI) 对所有原因死亡率的影响有矛盾的结果.
- 了解这种关联对于公共卫生指南和临床实践至关重要.
研究的目的:
- 调查身体体重,特别是身体质量指数 (BMI) 和全因死亡率之间的关联的性质.
- 检查吸烟和体力活动等因素如何影响BMI与死亡率的关系.
- 识别潜在的偏见,例如与疾病相关的体重减轻,可能会影响观察到的关联.
主要方法:
- 一项前性队列研究涉及19297名哈佛大学的男性校友,在1962年至1966年,他们的平均年龄为46.6岁.
- 参与者填写了关于体重,身高,吸烟习惯和身体活动的问卷;BMI是使用自我报告措施计算的.
- 随着年龄,吸烟和体力活动的调整,在多变量分析中追踪了所有原因的死亡率,直到1988年.
主要成果:
- 在整体队列中,BMI和全因死亡率之间观察到J形关系,BMI较高的死亡风险较高.
- 在目前的吸烟者中,发现了一个U形曲线,BMI为23.5至24.5.5的BMI死亡风险最低.
- 在排除早期随访和目前吸烟者以尽量减少混和偏见后,发现BMI和死亡率之间存在强烈的积极关联,最重的男性的风险最高.
结论:
- 在这个前性队列中,体重和死亡率是直接相关的,在较高的BMI中观察到死亡风险增加.
- 考虑到混因素和潜在的偏见,在更瘦的男性中没有发现过度死亡率.
- 最低的死亡风险在男性中观察到,他们的BMI大约低于美国年龄和身高平均水平的20%.
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