由折叠性胃化基因编码的假定细胞信号协调Drosophila胃化过程中细胞形状的变化
M Costa1, E T Wilson, E Wieschaus
1Department of Molecular Biology, Princeton University, New Jersey 08544.
Cell
|March 25, 1994
概括
折叠性胃化 (雾) 基因指导Drosophila发育过程中细胞形状的变化. 雾作为一个分泌信号,协调细胞通信,以实现基本的形态遗传运动,如腹腔的形成.
科学领域:
- 发育生物学 发展生物学
- 细胞生物学 细胞生物学
- 遗传学 是一个遗传学.
背景情况:
- 折叠性胃化 (雾) 基因对于果虫胃化至关重要.
- 雾调节了关键的形态遗传运动,包括腹腔的形成和后部中肠化.
研究的目的:
- 阐明雾基因在Drosophila胃化过程中协调细胞形状变化的作用.
- 为了研究雾引发顶尖收缩的机制.
主要方法:
- 在胚胎发生过程中分析雾基因表达模式.
- 过度表达研究以确定雾的功能领域.
- 研究雾与其他信号通路的相互作用.
主要成果:
- 雾表达式先于并准确地预测了收缩模式.
- 雾的过度表达会引起宫外收缩,这表明转录本地化决定了细胞形状的变化.
- 雾编码一种新型分泌蛋白质,可能会激活协奏曲G蛋白α子单元.
结论:
- 雾的功能是作为一个分泌的信号,在发育过程中协调细胞间的通信.
- 由雾介导的细胞-细胞信号确保及时和有组织的收缩启动适当的形态发生.
更多相关视频
07:15A Cell-based Assay to Investigate Non-muscle Myosin II Contractility via the Folded-gastrulation Signaling Pathway in Drosophila S2R+ Cells
Published on: August 19, 2018
9.6K
12:35Author Spotlight: Optogenetic Inhibition of Rho1-Mediated Actomyosin Contractility Coupled with Measurement of Epithelial Tension in Drosophila Embryos
Published on: April 14, 2023
2.0K
相关概念视频
02:32Position-effect Variegation
5.6K
In 1928, a German botanist Emil Heitz observed the moss nuclei with a DNA binding dye. He observed that while some chromatin regions decondense and spread out in the interphase nucleus, others do not. He termed them euchromatin and heterochromatin, respectively. He proposed that the heterochromatin regions reflect a functionally inactive state of the genome. It was later confirmed that heterochromatin is transcriptionally repressed, and euchromatin is transcriptionally active chromatin.
5.6K
02:02Cis-regulatory Sequences
9.5K
Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...
9.5K
02:32Exon Recombination
3.1K
The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes.
Exon shuffling follows “splice frame rules.” Each exon...
Exon shuffling follows “splice frame rules.” Each exon...
3.1K