一个质谱解决方案,以解决组合图书馆的地址问题
1Department of Chemistry, Pennsylvania State University, University Park 16802.
Science (New York, N.Y.)
|April 15, 1994
概括
研究人员使用质谱法确定了聚乙烯珠子上的分子重量. 这种方法选择性地切割,用于分析大型组合图书馆.
科学领域:
- 分析化学 分析化学
- 质谱测量质量谱测量
- 材料科学 材料科学 材料科学
背景情况:
- 在固体支上对小的表征对于组合化学至关重要.
- 分析珠子上的的传统方法可能是复杂和耗时的.
研究的目的:
- 开发一种方法,直接在聚乙烯珠上确定小的femtomole数量的分子重量.
- 为了能够直接描述庞大的组合图书馆.
主要方法:
- 使用成像飞行时间二次离子质谱法 (TOF-SIMS).
- 在TOF-SIMS分析之前,使用三酸蒸汽从珠子中切割的选择性键.
主要成果:
- 成功确定了粘附在30至60微米聚乙烯珠中的的分子量.
- 证明了同时分析大量珠子的可行性.
结论:
- 开发的TOF-SIMS方法允许直接和高效地确定珠子上的的分子量.
- 这种技术适用于大规模组合性库的高通量表征.
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