右心室和左心室功能在慢性心力衰竭中对呼吸系统对运动的反应中的作用
1Department of Cardiac Medicine, National Heart and Lung Institute, London, UK.
Circulation
|May 1, 1994
概括
右心室功能不是慢性心力衰竭患者运动能力的关键因素. 没有功能右心室的患者显示,运动能力下降和通风增加之间存在联系.
科学领域:
- 心脏病学 心脏病学
- 运动生理学 运动生理学
- 肺高血压是什么意思 肺高血压
背景情况:
- 右心室 (RV) 功能是慢性心力衰竭 (CHF) 运动能力的潜在决定因素.
- 了解RV功能对于管理CHF患者的运动限制至关重要.
研究的目的:
- 调查RV功能在CHF中的作用.
- 检查非存在的RV储备在Fontan手术后的患者对运动能力和呼吸反应的影响.
主要方法:
- 在运动期间的代谢气交换被测量在五组:Fontan患者 (没有功能VR),扩张性心肌病 (DCM) 控制,正常控制,CHF患者和额外的控制.
- 在CHF患者中,使用放射性核素心室摄影评估左心室和右心室喷射分数 (LVEF和RVEF).
主要成果:
- 与正常对照组相比,没有功能VR (Fontan组) 和DCM对照组的患者表现出明显更高的通风/二氧化碳 (VE/VCO2) 生产斜率.
- 在没有功能VR和DCM对照的患者中,在峰值氧气消耗 (VO2) 和VE/VCO2斜率之间观察到强烈的逆相关性.
- 在CHF患者中,VE/VCO2斜率明显高于对照组,但无论是RVEF还是LVEF都与峰值VO2或VE/VCO2斜率无关.
结论:
- 过度通风和降低峰值氧气消耗之间的关系在缺乏功能性右心室的个体中是明显的.
- 右心室喷射率 (RVEF) 似乎不是慢性心力衰竭中运动能力或呼吸系统反应的主要决定因素.
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