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人类严重的综合免疫缺陷是由于ZAP-70的缺陷引起的,ZAP-70是一种T细胞氨酸激酶

M E Elder1, D Lin, J Clever

  • 1Department of Pediatrics, University of California, San Francisco 94143-0110.

Science (New York, N.Y.)
|June 10, 1994
PubMed
概括

在ZAP-70 (zeta-chain-associated protein kinase 70) 中发生的突变会导致严重的综合免疫缺陷. 这项研究表明,ZAP-70对T细胞功能至关重要,对CD4+和CD8+T细胞信号产生不同的影响.

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