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预测严重的区域心室功能障碍的恢复. 静止光学与201Tl和99mTc-sestamibibiography的比较
J E Udelson1, P S Coleman, J Metherall
1Department of Medicine, Tufts University School of Medicine, Boston, Mass.
Circulation
|June 1, 1994
概括
201 (201Tl) 和技术-99m-sestamibi (99mTc-sestamibi) 两者都有效地识别了可行的心肌,并预测了冠状动脉疾病和左心室功能障碍患者在重血管化后恢复心脏功能.
科学领域:
- 心脏病学 心脏病学
- 核医学是一种核医学.
- 医疗成像医学成像
背景情况:
- 静止注射后的201T1区域活性反映了可行的心肌,并预测了再血管化后的功能.
- 99mTc-sestamibi具有明显的动力学与最小的再分配,可能有利于检测可行的心肌在hyperfused段.
研究的目的:
- 在休息注射后比较201Tl和99mTc-sestamibi的区域活动.
- 评估它们在预测重血管化后严重区域心室功能障碍的恢复方面的比较能力.
主要方法:
- 在31名患者中,对休息/再分配201T1和1小时休息99mTc-sestamibi活性进行了定性和定量比较.
- 用于对每位患者12个细分的定量分析的周围形状.
- 2D回声心电图用于评估墙壁运动和厚度,与SPECT数据相关联.
主要成果:
- 通过视觉分析,区域201Tl再分配和 sestamibi活动之间87%的一致性.
- 定量区域性201Tl再分配和 sestamibi活动之间存在显著的相关性 (r=.86).
- 在可逆性和不可逆性功能障碍细分市场中,两种代理商的类似区域活动.
- 功能障碍恢复的可比正 (75-80%) 和负 (92-96%) 预测值.
结论:
- 量化的sestamibi活动与再分配201Tl活动平行,表明复杂的sestamibi处理超出了纯流量追踪器.
- 201Tl和99mTc-sestamibi都能区分可行的心肌与不可行的心肌.
- 这两种药物比较地预测了在再血管化后墙壁运动异常的可逆性.
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