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Updated: Aug 10, 2026

Intralymphatic Immunotherapy and Vaccination in Mice
07:33

Intralymphatic Immunotherapy and Vaccination in Mice

Published on: February 2, 2014

缺少双白素-2 的小鼠免疫反应

T M Kündig1, H Schorle, M F Bachmann

  • 1Institute of Experimental Immunology, University of Zürich, Switzerland.

Science (New York, N.Y.)
|November 12, 1993
PubMed
概括

干白素-2 (IL-2) 在体外对T细胞反应至关重要. 然而,缺乏IL-2的小鼠在体内显示出很大程度上正常的免疫功能,挑战IL-2的功能.

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T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...