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Updated: Aug 14, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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Published on: October 26, 2015

细胞循环控制中的一个新的调节动机导致了环林D/CDK4的特定抑制

M Serrano1, G J Hannon, D Beach

  • 1Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, New York 11724.

Nature
|December 16, 1993
PubMed
概括

一种新发现的蛋白质,p16,与循环素依赖性激酶4 (CDK4) 结合并抑制其活性. 这一发现揭示了一个新的调控反电路,控制细胞分裂和增殖.

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