DNA

S Klimasauskas1, S Kumar, R J Roberts

  • 1W. M. Keck Structural Biology Laboratory, Cold Spring Harbor, New York 11724.

Cell
|January 28, 1994
PubMed
概括

晶体结构揭示了HHAI DNA甲基转移酶如何结合DNA,捕获反应中间体. 这为细胞因子-5DNA甲基化机制和一种新的DNA识别模式提供了直接证据.

相关概念视频

Mismatch Repair01:36

Mismatch Repair

Overview
DNA Helicases00:55

DNA Helicases

DNA unwinding helicase enzymes are a type of motor protein. Motor proteins can translocate along filaments or polymers using energy generated from ATP hydrolysis. Helicases are involved in all the important cellular processes where DNA unwinding is required, such as DNA replication, repair, recombination, and transcription. They are present in all living organisms, but vary in their structure, function, and mechanism of action. For example, in prokaryotes, DnaB helicase binds and translocates...
Mismatch Repair01:36

Mismatch Repair

Overview
Base Excision Repair01:54

Base Excision Repair

One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing and strand breakage during replication. This type of damage causes minimal change to the DNA double helix structure and can be repaired by the base excision repair (BER) pathways. BER corrects damaged DNA sequences by removing the damaged base and restoring the original base sequence using the complementary strand as a template.
The first step of...