无脂蛋白多态性不能定义冠状动脉疾病的风险. 一个前性的,血管图学控制的研究结果
H W Marshall1, L C Morrison, L L Wu
1Department of Human Genetics, University of Utah School of Medicine, Salt Lake City.
Circulation
|February 1, 1994
概括
在阿波利波蛋白基因中常见的遗传多态性并没有显著影响冠状动脉疾病 (CAD) 的风险. 这项研究没有发现证据支持对这些遗传标记物进行大规模查,以识别患有CAD高风险个体.
科学领域:
- 遗传学 是一个遗传学.
- 心血管疾病 心血管疾病
- 分子生物学分子生物学
背景情况:
- 遗传因素与冠状动脉疾病 (CAD) 的病因有关.
- 由于它们在脂质代谢和CAD风险中的作用,Apolipoprotein基因是候选位点.
- 以前的研究表明,阿波利波蛋白基因多态和CAD风险之间存在相互矛盾的关联.
研究的目的:
- 为了确定阿波利波蛋白基因多态化是否可以识别患有CAD风险增加的个体.
- 解决关于阿波利波蛋白多态和CAD之间的关联的相互矛盾的发现.
- 为了评估12个阿波利波蛋白遗传多态的分布在接受冠状动脉血管学的大队伍中.
主要方法:
- 评估了848名接受冠心血管造影的受试者,将他们分为CAD患者 (n=444) 和对照组 (n=404).
- 在阿波利波蛋白位点 (apo A-I/C-III/A-IV,apo B,apo A-II,apo C-II,apo E) 中评估了12种多态.
- 利用日志线性模型来分析多形态和CAD风险之间的关联,控制人口和临床因素.
主要成果:
- 在12种阿波利波蛋白多形体和患血管学定义CAD的风险之间没有发现任何显著的关联 (P = .10到 .90).
- 这种缺乏关联性甚至在分析特定子组时也存在,例如年轻的患有早期CAD的患者.
- 所有评估的位置都处于哈迪-韦恩伯格平衡状态,这表明没有人口异质性.
结论:
- 主要阿波利波蛋白基因中常见的遗传多态性并没有显著影响血管学定义的CAD的风险.
- 对这些遗传多态度的群体查不被支持作为一种策略来识别患有CAD高风险的个体.
- 建议专注于修改高风险行为,以减轻传统环境风险因素对CAD的影响.
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