间歇性和连续性给药的对比效应 赫巴林在实验性回中
1Department of Medicine (Cardiovascular Division, Brigham and Women's Hospital), Boston, MA 02115.
Circulation
|February 1, 1994
概括
肝素的施用方法显著影响血管损伤的结果. 不同于间歇性注射,连续的注射有效地减少了光滑肌肉细胞的增殖和内脏增生.
科学领域:
- 血管生物学 血管生物学
- 药理学 药理学是指药理学的学科.
- 生物医学工程 生物医学工程
背景情况:
- 氨酸在实验模型中显示出抑制平滑肌肉细胞增殖和内脏增生的抑制作用.
- 临床试验显示,肝素对血管损伤的悖论性恶化,这表明服用方法存在差异.
- 调查各种各样的肝素给药方案对于调和相互矛盾的实验和临床发现至关重要.
研究的目的:
- 为了确定氨酸施用方法的差异是否解释了它对血管损伤的不同影响.
- 在临床前模型中检查一系列肝素治疗的血管效应.
主要方法:
- 实验室老鼠在不同的频率 (每隔一天,每天,每天两次) 和剂量下接受皮下肝素注射.
- 通过输入静脉输注的透和周血管聚合物装置实现了连续的肝素输送.
- 在动脉损伤后评估了内密增生,内密与中间面积比,以及细胞增殖.
主要成果:
- 皮下肝素给药,模仿临床方案,加剧了内脏增生.
- 持续的静脉和周脉肝素输送显著抑制了内脏增生和光滑肌肉细胞增殖.
- 间歇性肝素注射增加了激活的局部血栓形成时间,而连续注射并没有改变凝血参数.
结论:
- 肝素的施用方法极大地影响了它在血管损伤中的治疗效果.
- 持续的肝素输送显示,有望缓解内脏增生和血管损伤.
- 重新评估肝素在血管疾病的临床使用是有必要的,考虑到给药途径.
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