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Updated: Aug 19, 2026

Deciphering Axonal Pathways of Genetically Defined Groups of Neurons in the Chick Neural Tube Utilizing in ovo Electroporation
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发展中的哺乳动物中枢神经系统中轴突的化学排斥

A Pini1

  • 1Medical Research Council Mammalian Development Unit, London, United Kingdom.

Science (New York, N.Y.)
|July 2, 1993
PubMed
概括

发育中的轴突使用指导线索在复杂的环境中导航. 这项研究揭示了排斥信号如何创建"排斥区",引导神经细胞生长远离不正确的区域.

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...