低剂量多布他胺心声扫描检测了急性心肌梗塞的血栓治疗后可逆性功能障碍
1Krannert Institute of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis.
Circulation
|August 1, 1993
概括
低剂量多布他胺心声学准确地识别了心肌梗塞 (MI) 和血栓治疗后可逆性心脏功能障碍. 这种方法对所有心脏病发作地点都具有敏感性,有助于早期检测康复.
科学领域:
- 心脏病学 心脏病学
- 医疗成像医学成像
- 药理学 药理学是指药理学的学科.
背景情况:
- 心肌梗塞 (MI) 可以导致可逆或不可逆的心肌功能障碍.
- 区域壁运动异常在心脏病发作后的早期很常见.
- 多布他胺心声学 (DE) 评估改善的墙壁加厚 (多布他胺响应的墙壁运动) 以确定可逆损伤.
研究的目的:
- 为了评估是否dobutamine-responsive墙壁运动准确地检测可逆性后缺血功能障碍.
- 为了确定准确度,不论心脏病发作位置在血栓消毒疗法后.
- 为了比较DE与早期反的迹象,非Q波MI,以及激酶 (CK) 峰值.
主要方法:
- 多个阶段的多巴胺心声图 (DE) 在急性心肌梗塞的血栓治疗后7天内进行.
- 在4和12微克的Dobutamine输注.kg-1.min-1,和峰值水平.
- 休息回声心脏图重复>或=4周后MI以确定可逆性功能障碍.
主要成果:
- 在63名患者中安全地进行了DE;在51名 (81%) 进行了随访.
- 在22名患者 (41%) 中,墙壁运动得到改善.
- 低剂量DE (4微克.kg-1.min-1) 显示出高特异性 (90-93%) 和敏感性 (86%) 对于所有心脏病发作位置的可逆性功能障碍. 非Q波MI和低峰CK是特定的,但不那么敏感.
结论:
- 在急性心脏病发作中,多阶段的多巴胺心声图是急性心脏病发作中血栓解压药物治疗后的早期安全.
- 低剂量dobutamine-responsive墙壁运动准确地检测所有心脏病发作地点的可逆功能障碍.
- 答应多布他胺的墙壁运动和非Q波心脏病发作对于识别早期可逆性功能障碍后MI.
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