概括
传统的胰岛素含有胰腺激素,导致许多胰岛素依赖糖尿病患者产生高亲和度抗体. 这些阳性抗体向胰腺细胞和神经,引发了对长期糖尿病治疗的担忧.
科学领域:
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
- 糖尿病学 糖尿病学
背景情况:
- 商用胰岛素制剂通常含有诸如胰腺多 (P.P.P.) 等污染物. ),血管活性肠 (V.I.P. ) 和体静止素.
- 这些污染物在高度净化或单组分胰岛素中基本上不存在.
研究的目的:
- 为了研究胰腺激素抗体在胰岛素依赖糖尿病患者的存在.
- 为了确定常规胰岛素使用与阳性自身免疫的发展之间的关联.
主要方法:
- 对胰岛素依赖糖尿病患者,成熟期糖尿病患者,健康对照患者和单组分胰岛素患者的循环抗体的分析.
- 免疫细胞化学测试以评估对产生激素的细胞和神经的抗体特异性.
主要成果:
- 接受常规胰岛素的胰岛素依赖糖尿病患者中,有63%对PP具有抗体,对VIP,葡萄糖和体静止素的百分比较低.
- 抗体的亲和力很高,在年轻的糖尿病患者中更为普遍.
- 在对照组或接受单元胰岛素的患者中没有检测到抗体,这表明有阳性致病原因.
结论:
- 常规胰岛素的使用可以诱导胰岛素依赖的糖尿病患者的阳性自身免疫.
- 这些抗体的存在引发了关于传统胰岛素治疗的长期影响的重大问题.
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