相关实验视频
Updated: Aug 2, 2026

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A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome
Published on: October 2, 2018
蒙古子中获得特征的荷尔蒙介导遗传
M M Clark1, P Karpiuk, B G Galef
1Department of Psychology, McMaster University, Hamilton, Ontario, Canada.
Nature
|August 19, 1993
概括
雌性动物胎儿在子宫内接触到雄性兄弟姐妹时,会发生雄性化,改变成人的行为. 这些母亲倾向于产生更多的男性后代,将雄激素化特征传给他们的女儿.
科学领域:
- 发育生物学是发展生物学.
- 动物行为 动物行为
- 内分泌学 在内分泌学.
背景情况:
- 宫内位置影响动物的胎儿发育和成人表型.
- 在子宫内暴露于雄激素可以导致形态和行为的显著变化.
- 以前的研究表明,子宫内定位的性别特异性影响.
研究的目的:
- 为了研究子宫内位置对蒙古大鼠后代性别比率的影响.
- 为了确定在子宫中暴露于雄性胎儿的成年雌性大鼠是否会产生与暴露于雌性胎儿的雌性大鼠相比不同的子.
- 探索一代相继继继承的雄激素化表型.
主要方法:
- 根据他们自己的子宫内定位 (男性与女性之间的孕期) 进行了成年雌性蒙古鹿的 litter 性比比较.
- 蒙古大鼠生殖结果的观察性研究.
- 与子宫内暴露相关的母体和后代表型的分析.
主要成果:
- 在雄性胎儿之间孕育的雌性 gerbils 产生的子具有明显更高比例的儿子.
- 孕育在男性之间母亲的女儿更有可能在子宫内被安德罗基化.
- 跨世代观察到一代人对雄激素化表型的遗传倾向.
结论:
- 宫内定位会影响幼鼠的后代性别比率.
- 在子宫内发生的雄激素化会影响母亲的生殖策略.
- 这项研究表明了哺乳动物发育表型遗传的潜在机制.
相关概念视频
Pedigree Analysis
Overview
Epistasis
In addition to multiple alleles at the same locus influencing traits, numerous genes or alleles at different locations may interact and influence phenotypes in a phenomenon called epistasis. For example, rabbit fur can be black or brown depending on whether the animal is homozygous dominant or heterozygous at a TYRP1 locus. However, if the rabbit is also homozygous recessive at a locus on the tyrosinase gene (TYR), it will have an unshaded coat that appears white, regardless of its TYRP1...
Genomic Imprinting and Inheritance
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
Background and Environment Affect Phenotype
Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
Dosage Compensation
In animals, gender is determined by the number and type of sex chromosome. For example, human females have two X chromosomes, and males have one X and one Y chromosome, whereas C.elegans with one X chromosome is a male, and the one with two X chromosomes is a hermaphrodite.
In addition to sexual development, the X chromosome has genes involved in autosomal functions such as brain development and the immune system. Therefore, males and females with distinct numbers of X chromosomes will have...
In addition to sexual development, the X chromosome has genes involved in autosomal functions such as brain development and the immune system. Therefore, males and females with distinct numbers of X chromosomes will have...
Inheritance
Gregor Mendel's pioneering work on the principles of inheritance fundamentally transformed our understanding of how traits are transmitted from generation to generation. His experiments with pea plants laid the groundwork for the discovery of genes, discrete units within organisms that control heredity.
Each gene exists in pairs, and the combination of these genes from both parents forms an individual's genotype. This genotype is a blueprint of potential traits. Examples of genotype traits...
Each gene exists in pairs, and the combination of these genes from both parents forms an individual's genotype. This genotype is a blueprint of potential traits. Examples of genotype traits...

