对家族病史和乳腺癌风险进行全面评估. 犹他州的人口数据库
1Department of Family and Preventive Medicine, University of Utah School of Medicine, Salt Lake City 84132.
JAMA
|October 6, 1993
概括
乳腺癌家族病史显著增加女性的风险,甚至远亲也会导致更高的几率. 大约17-19%的乳腺癌病例与遗传倾向有关.
科学领域:
- 在瘤学瘤学.
- 遗传学 是一个遗传学.
- 流行病学 流行病学
背景情况:
- 家庭病史是乳腺癌的已知危险因素.
- 了解家族风险的程度对于风险评估和预防策略至关重要.
研究的目的:
- 评估家族病史对乳腺癌风险的影响.
- 使用综合数据集量化家庭病史和乳腺癌发展之间的关联.
主要方法:
- 采用了一种病例控制研究设计.
- 利用犹他州人口数据库,将家谱,癌症和死亡率数据联系起来.
- 包括被诊断患有乳腺癌的妇女和没有癌症史的匹配对照.
主要成果:
- 在家族史得分最高的个体中,乳腺癌的风险增加了三倍.
- 乳腺癌的几率比 (OR) 是2.45对于一级亲属,1.82对于二级亲属,和1.35对于三级亲属.
- 据估计,家庭病史占人口中乳腺癌病例的17-19%.
结论:
- 患有乳腺癌家族史的女性,即使是三度亲属,也面临着更高的风险.
- 家庭病史是乳腺癌发展的重要,可量化的风险因素.
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