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病中的心脏抑郁因子
Circulation
|May 1, 1993
概括
慢性和急性衰竭中的心脏功能障碍可能源于特定的心肌抑郁因子. 研究表明,这些毒素是可过的,并且在功能衰竭类型和败血症之间存在差异.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心脏病学 心脏病学
- 毒理学 毒理学 毒理学
背景情况:
- 慢性功能衰竭 (CRF) 和急性功能衰竭 (ARF) 与心脏功能障碍有关,特别是当ARF涉及败血症时.
- 虽然在CRF中注意到纤维化,但功能性心肌病也会发生.
- 乙酸和二次性甲状腺功能过高不太可能是尿血中主要的心肌抑郁剂.
研究的目的:
- 调查CRF和ARF患者心肌抑制因子的存在和性质.
- 探索这些因素在尿路性心肌病症中的潜在作用.
- 在CRF,ARF和败血症中区分抑郁因子.
主要方法:
- 从接受透析的CRF和ARF患者的血清分数和超的分析.
- 对卡尼丁缺乏症研究数据的评估 (尽管指出控制不良).
- 对实验的回顾,这些实验表明了抑郁剂物质的分子量.
主要成果:
- 来自CRF和ARF患者的血清分离物表现出心肌抑郁作用.
- 连续血过在多器官衰竭中的好处支持了这些因素的作用.
- 有证据表明,在CRF,ARF和败血症中存在不同的抑郁因子,不同的分子重量被提出 (500-5,000d,>10,000d,目前被认为是10,000-30,000d).
结论:
- 这项研究证实了由于可过毒素导致的功能衰竭中存在"特异性心肌病".
- 心肌抑制因子存在于尿血和败血症中.
- 这些因素似乎在CRF,ARF和败血症中是不同的.
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