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一种在子宫内使雌性斑点子病毒化的机制
T M Yalcinkaya1, P K Siiteri, J L Vigne
1Department of Obstetrics, Gynecology, University of California School of Medicine, San Francisco 94143.
概括
雌性斑点子由于高水平的androstenedione,具有类似男性的生殖器. 狗中的有限的芳酶活性将这种前体转化为丸激素,导致雄性化,并可能影响卵巢发育.
科学领域:
- 进行比较内分泌学.
- 生殖生物学 生殖生物学
- 哺乳动物生理学哺乳动物生理学
背景情况:
- 斑点的女表现出独特的男性化外部生殖器和社会主导地位.
- 女性斑点的这些表型特征背后的荷尔蒙机制仍然不完全理解.
研究的目的:
- 为了研究斑点子卵巢和胎盘组织的类固醇活性.
- 阐明安德罗二及其转化酶在雌性海病毒化中的作用.
主要方法:
- 在实验室内化斑点子卵巢组织,以测量类固醇激素的产量.
- 酶分析比较了和人类胎盘同质体中的芳酶和17β-基类固醇脱酶活性.
主要成果:
- 的卵巢组织产生了大量的androstenedione.
- 与人类胎盘相比,驼胎盘中的芳酶活性显著降低.
- 17β-hydroxysteroid脱酶的活性在和人类胎盘同质体之间是可比的.
结论:
- 斑点的胎盘芳酶活性较低可能有利于从androstenedione产生丸激素,导致胎儿外部生殖器官的病毒化.
- 卵巢 stromal 细胞的安德罗二生产有助于在成年女性男性化的表观遗传传.
相关概念视频
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The Y Chromosome Determines Maleness
The Y chromosome is a sex chromosome found in several vertebrates and mammals, including humans. In addition to 22 pairs of autosomes, the human males have one X chromosome and one Y chromosome. In these organisms, the presence or absence of the Y chromosome determines the development of male traits.
Evolution
Around 300 million years ago, the two sex chromosomes diverged from two identical autosomal chromosomes. Over time, the Y chromosome has lost most of its genes, shrinking in size. Today,...
Evolution
Around 300 million years ago, the two sex chromosomes diverged from two identical autosomal chromosomes. Over time, the Y chromosome has lost most of its genes, shrinking in size. Today,...
The Ratio of X Chromosome to Autosomes
In most organisms, sex is determined by the ratio of X and Y chromosomes. However, in some organisms, such as Drosophila and C.elegans, sex is determined by the ratio of the number of X chromosomes to the number of sets of autosomes. The Y chromosome in Drosophila is active but does not determine sex. It contains genes responsible for the production of sperms in adult flies.
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female Drosophila...
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female Drosophila...
Development of the Sexual Organs in the Embryo and Fetus
Development of the reproductive organs in an embryo starts from a bipotential state. This means the early embryo can develop either male or female reproductive organs. The formation of these organs begins with the growth of gonadal ridges that arise from the intermediate mesoderm during the fifth week of development.
Near the gonadal ridges, two duct systems are present: the mesonephric ducts (Wolffian ducts) and paramesonephric ducts (Müllerian ducts). These ducts form the basis for the male...
Near the gonadal ridges, two duct systems are present: the mesonephric ducts (Wolffian ducts) and paramesonephric ducts (Müllerian ducts). These ducts form the basis for the male...

