高压氧限制心脏病发作大小在缺血子心肌 in vivo
D L Sterling1, J D Thornton, A Swafford
1Department of Biological Sciences, University of South Alabama, Mobile 36688.
Circulation
|October 1, 1993
概括
在子中,高压氧气疗法显著降低了回流损伤后的心肌损伤. 这种保护作用是通过在再注射过程中给予高压氧气来实现的.
科学领域:
- 心脏病学 心脏病学
- 高压医学的高压医学.
- 缺血-再输液损伤 缺血-再输液损伤
背景情况:
- 心肌缺血和再注血 (I/R) 损伤是一个重要的临床问题.
- 为了改善患者的治疗结果,研究减轻I/R后亡的方法至关重要.
研究的目的:
- 评估高压氧 (HBO) 降低心脏病发作大小的疗效,在子心肌梗塞I/R模型中.
- 为了确定HBO的最佳时间来实现心脏保护.
主要方法:
- 使用开放胸部的子模型,包括30分钟的左冠状动脉分支的封闭,然后再输血3小时.
- 通过使用三四醇染色量化发作.
- 在I/R过程的不同阶段,动物被暴露在100%的正常氧 (1 atm绝对) 或高压氧 (2.5 atm绝对) 中.
主要成果:
- 对照动物 (1 atm氧气) 呈现41.5%的缺血区心脏病发作.
- 在缺血,再注血或两者期间的高压氧气治疗显著减少了心脏病发作的大小 (分别为16.2%,14.5%和9.8%;P < .01).
- 在再输血开始后30分钟启动HBO并没有提供保护 (35.8%的心脏病发作).
结论:
- 高压氧气疗法在子心肌再注射损伤的设置中有效地限制了心脏病发作的大小.
- 在重灌开始时,HBO的心脏保护性益处是显而易见的.
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