一种用于核磁共振显微镜的高温超导接收器
R D Black1, T A Early, P B Roemer
1General Electric Corporate Research and Development Center, Schenectady, NY 12301.
Science (New York, N.Y.)
|February 5, 1993
概括
一个新的高温超导接收器增强了核磁共振 (NMR) 显微镜. 该系统克服了热噪声限制,提高了生物成像的分辨率.
科学领域:
- 物理 物理学 物理
- 生物物理学的生物物理.
- 材料科学 材料科学 材料科学
背景情况:
- 核磁共振 (NMR) 显微镜可提供高分辨率成像,但通常受噪声的限制.
- 接收器线圈噪声,特别是约翰逊 (热) 噪声,是限制NMR系统分辨率的重要因素.
研究的目的:
- 描述一个用于NMR显微镜的高温超导接收器系统.
- 分析噪声源并确定NMR分辨率的主要限制.
- 研究在生物成像NMR实验中使用超导体的可行性.
主要方法:
- 开发和描述一个高温超导接收系统.
- 对样本和接收机-线圈噪声的缩放行为的分析.
- 在NMR实验环境中检查超导体行为.
- 使用开发的系统获取初步的回旋回声图像.
主要成果:
- 证明接收器线圈中的约翰逊 (热) 噪声是NMR分辨率的限制因素.
- 在NMR实验条件下对超导体的行为进行表征.
- 成功获得了生物标本的初步回旋回声图像.
- 对NMR探针的信号噪声比极限的研究.
结论:
- 高温超导接收器可以显著改善NMR显微镜.
- 了解和减轻热噪声对于推进NMR分辨率至关重要.
- 开发的系统显示出使用NMR显微镜进行高分辨率生物成像的前景.
相关概念视频
01:31Transducer Mechanism: Nuclear Receptors
Nuclear receptors, or NRs, are unique transcription factors that regulate gene transcription and affect the cellular pathways involved in reproduction, development, or metabolism. Their ability to be stimulated by small lipophilic ligands and control vital cellular processes makes them ideal drug targets. Nearly 10-15% of currently prescribed drugs target these receptors.
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
01:12Double Resonance Techniques: Overview
Double resonance techniques in Nuclear Magnetic Resonance (NMR) spectroscopy involve the simultaneous application of two different frequencies or radiofrequency pulses to manipulate and observe two distinct nuclear spins. One important application of double resonance is spin decoupling, which selectively suppresses coupling with one type of nucleus while observing the NMR signal from another nucleus, simplifying the spectrum and enhancing resolution.
Spin decoupling is usually achieved by...
Spin decoupling is usually achieved by...