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确定免疫干预的策略

A Lanzavecchia¹

¹Basel Institute for Immunology, Switzerland.

Science (New York, N.Y.)

|May 14, 1993

概括

了解T细胞识别和激活途径可以进行免疫系统干预. 这些知识有助于开发疫苗,抗瘤反应,以及管理自身免疫性疾病和移植排斥.

科学领域:

免疫学免疫学免疫学
分子生物学分子生物学
疫苗学疫苗学疫苗学

背景情况:

人们越来越了解T细胞抗原识别的分子机制.
正在确定调节T细胞激活和专业化的途径.

研究的目的:

为治疗策略利用T细胞生物学最近的进展.
探索疫苗开发,癌症免疫疗法和移植/自身免疫性疾病管理的干预措施.

主要方法:

对T细胞抗原识别的分子分析.
揭示T细胞激活和功能途径.

主要成果:

详细了解T细胞如何识别抗原.
定义了控制T细胞激活和专业化的途径.

结论:

了解T细胞通路使得有针对性的免疫系统干预成为可能.
可以为疫苗,瘤免疫,移植耐受性和自身免疫性疾病控制设计策略.

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