概括
对大多数鼻节律患者,特别是那些血水平较低的患者来说,停止服用狄戈辛是安全的. 86%的患者成功停止治疗,较低的水平表明更高的成功率.
科学领域:
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 迪戈辛是一种长期存在的心脏糖化物,用于心力衰竭和心律失常.
- 评估长期狄戈辛治疗的必要性对于患者管理至关重要.
研究的目的:
- 评估在患有鼻节律的患者中中止长期迪戈辛治疗的可行性和安全性.
- 为了确定成功提素戒断的预测因素.
主要方法:
- 一组56名患者长期接受毒素与鼻节律的治疗,药物已停止使用.
- 血滴毒素度在戒药前进行测量.
- 停药后对临床状态和心律失常或心力衰竭的发展进行了监测.
主要成果:
- 86%的患者 (48/56) 在没有临床恶化的情况下成功停止了迪戈辛的治疗.
- 在戒断前血滴氧素水平<0.8 ng/ml的患者的成功率很高 (33/34).
- 恶化,主要是新发动的心房动,发生在22名患者中的7名患者中,其水平在0.8-2.0 ng/ml之间.
结论:
- 在大多数有鼻节律的患者中,停用迪戈辛是可行的.
- 较低的基线血digoxin度与成功的戒断有关.
- 在断药时,监测心房动是必不可少的.
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