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Updated: Jan 6, 2026

Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow
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Published on: October 17, 2025

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在V(D) J重组信号上的裂变只需要RAG1和RAG2蛋白质,并且发生在两个步骤中

J F McBlane1, D C van Gent, D A Ramsden

  • 1Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0540, USA.

Cell
|November 3, 1995
PubMed
概括

纯化的RAG1和RAG2蛋白质通过在信号序列中创建双链断裂来启动V(D) J重组. 这一过程涉及切断一个线程,然后打破另一个线程,形成一个编码末端的发针结构.

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