INK4a瘤抑制基因的替代阅读框架编码了两种无关的蛋白质,能够诱导细胞循环停止

D E Quelle1, F Zindy, R A Ashmun

  • 1Howard Hughes Medical Institute, St. Jude Children's Research Hospital, Memphis, Tennessee 38101, USA.

Cell
|December 15, 1995
PubMed
概括

在INK4a基因产生两个细胞循环抑制剂,p16INK4a和p19ARF. 这种双重功能基因通过控制细胞周期进展,对预防癌症至关重要.

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