在ACE基因I/D多态的插入等位基因. 抗胰岛素的一个候选基因?
A Panahloo1, C Andrès, V Mohamed-Ali
1Department of Medicine, University College London Medical School, Whittington Hospital, England.
Circulation
|December 15, 1995
概括
血管氨酸转化酶 (ACE) 删除基因型 (DD) 与冠心病 (CHD) 风险增加有关. 这项研究没有发现与胰岛素抵抗有任何关联,但在具有DD基因型的NIDDM受试者中显示胰岛素敏感性增加.
科学领域:
- 遗传学 是一个遗传学.
- 心血管疾病 心血管疾病
- 代谢综合征是代谢综合征的一种.
背景情况:
- 血管激素转化酶 (ACE) 插入/删除 (ID) 多态与冠心病 (CHD) 有关,但潜在的机制尚不清楚.
- 这项研究调查了ACE基因缺失等位基因与胰岛素抵抗之间的潜在关联.
研究的目的:
- 测试该假设,即ACE基因的删除等位基因与胰岛素抵抗有关.
- 探索ACE基因型与胰岛素抵抗综合征的组成部分之间的关系.
主要方法:
- 进行了ACE插入/删除 (ID) 多态的基因定型.
- 在103名非胰岛素依赖型糖尿病患者 (NIDDM) 和533名非糖尿病白人受试者中测量了胰岛素敏感性,胰岛素水平和des 31,32的亲胰岛素.
- 分析包括ANOVA和HOMA%计算.
主要成果:
- 与ID和II基因型相比,具有DD基因型的NIDDM受试者表现出明显较低的特定胰岛素水平.
- 不接受胰岛素治疗的DD基因型受试者表现出胰岛素敏感性增加和更低的亲胰岛素水平.
- 在糖尿病或非糖尿病组中,在ACE基因型之间没有观察到心脏病发病率,血压,血清脂质或PAI-1活性的显著差异.
结论:
- 与ACE DD基因型相关的心血管风险增加并非由胰岛素抵抗或纤维素分解异常介导.
- 在携带ACE DD基因型的NIDDM受试者中观察到胰岛素敏感性增加.
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