冠状病毒肺炎 (TWAR) 在动脉动脉样硬化中
J T Grayston1, C C Kuo, A S Coulson
1Department of Epidemiology, University of Washington, Seattle 98195-7236, USA.
Circulation
|December 15, 1995
概括
克拉米迪亚肺炎细菌经常被检测到动脉动脉样硬化组织从患者进行Endarterectomy. 需要进一步的研究来探索这种感染在动脉疾病中的潜在作用.
科学领域:
- 心血管研究研究心血管研究
- 传染病病理学 传染病病理学
- 微生物学 微生物学
背景情况:
- 克拉米迪亚肺炎已在大动脉和冠状动脉的动脉硬化病变中被确定.
- 之前的一项血清流行病学研究表明,与对照人群相比,动脉壁显著加厚的人群中,C. pneumoniae抗体的患病率较高.
研究的目的:
- 为了调查冠状病毒肺炎在动脉内关节切除样本中的存在.
- 为了确定C. pneumoniae和动脉动脉样硬化之间的关联.
主要方法:
- 免疫细胞化学 (ICC) 和聚合酶连锁反应 (PCR) 用于检测C. pneumoniae在新鲜冷和甲胺固定的喉内关节切除组织中.
- 56名患者的档案甲固定,嵌组织也使用ICC进行了检查.
- 来自6名患者的正常动脉组织作为对照组.
主要成果:
- 所有五个新鲜冷和甲固定的耳末切除术标本都被ICC检测为C. pneumoniae阳性,PCR证实其存在于三个.
- 在56个档案组织的ICC分析中,32个标本中发现了C. pneumoniae.
- 在13个正常的动脉组织部位中,检测出C. pneumoniae的阴性.
结论:
- 克拉米迪亚肺炎有机体经常存在于经过动脉切除术的患者的晚期动脉样硬化病变中.
- 这些发现表明C. pneumoniae在动脉动脉样硬化中的潜在因果或致病作用,需要进一步调查.
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