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Updated: Jul 28, 2026
08:04
Murine Fetal Echocardiography
Published on: February 15, 2013
胎儿回声性肠道的预后影响
1Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Norfolk 23507, USA.
Lancet (London, England)
|January 13, 1996
概括
对胎儿回声性肠道的新分级系统有助于诊断囊性纤维化 (CF) 和三症-21. 在胎儿中,中度至重度的回声性肠炎需要对这些疾病进行基因检测.
科学领域:
- 医疗成像医学成像
- 产前诊断 在产前诊断
- 遗传学 是一个遗传学.
背景情况:
- 在超声波上增加的胎儿回声性肠道与囊性纤维化 (CF) 和三症-21有关.
- 以前的诊断局限性是由于缺乏标准化回声性测量.
- 这项研究解决了对胎儿肠道回声性进行定量评估的需要.
研究的目的:
- 开发和验证胎儿回声性肠道的超声波分级系统.
- 评估这种分级系统在识别胎儿遗传异常时的诊断效用.
- 为了确定基因检测的阳性确诊率在胎儿与回声性肠道.
主要方法:
- 设计了一种全新的超声波分级系统,通过线性增益减小和与胎儿腹腔脊相比较来量化回声效应.
- 从7400个第二个三个月的超声波推中,确定了145个具有异常回声性肠道的胎儿.
- 提供了遗传咨询,CF的载体检测,以及Karyotype和CF状态的羊水切片检测.
主要成果:
- 在胎儿中没有发现患有轻度回声性肠道 (1级) 的CF或动脉质病例.
- 适度的回声性肠道 (2级) 与三发症21 (2例) 和CF (2例) 相关.
- 显著的回声性肠道 (3级) 与CF (5例) 和三体-21 (6例) 的相关性更高.
结论:
- 开发的超声波分级系统有效量化胎儿肠道回声性.
- 胎儿的二级和三级回声性肠道对CF和动脉积分症等遗传疾病的阳性确诊率很高.
- 父母CF载体测试和羊水切割是宝贵的工具,用于诊断胎儿CF和动脉化,当检测到声源性肠.
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