多态性在Drosophila调节基因Ultrabithorax中的多态性对同源稳定性的影响
1Department of Biology, University of Michigan, Ann Arbor 48109-1048, USA.
概括
果的发育稳定性与Ultrabithorax (Ubx) 基因有关. 在Ubx中的遗传变异影响了基因如何保持胸部段的身份,以抵御环境和遗传破坏.
科学领域:
- 发育生物学是发展生物学.
- 分子遗传学 分子遗传学
- 遗传学 遗传学是一种遗传学.
背景情况:
- 发育性平衡缓冲生物体对环境和遗传干扰.
- 超比索拉克斯 (Ubx) 基因对于在Drosophila melanogaster.中建立胸部细分标识至关重要.
- 了解发育稳定的遗传基础是理解进化过程的关键.
研究的目的:
- 为了研究发育恒温的分子遗传基础.
- 分析Ultrabithorax (Ubx) 基因在维持胸部细分标识中的作用.
- 为了确定对Drosophila的转录稳定性有助于转录的遗传变异.
主要方法:
- 人工选择被用来创造具有对以太气蒸气诱导的 bithorax 现象拷贝差异敏感性的飞线.
- 进行了分子遗传分析,以评估基因表达和识别多态性.
- 第三个胸部影像盘被检查了Ultrabithorax (Ubx) 基因表达模式.
主要成果:
- 对以太气蒸气增加的敏感性与第三胸部影像盘中的Ultrabithorax (Ubx) 表达减少相关.
- 转录稳定性遗传变异的很大一部分与Ultrabithorax (Ubx) 基因多态性有关.
- 这些发现凸显了UBX在缓冲发育过程中的作用.
结论:
- 在Ultrabithorax (Ubx) 基因中的多态化有助于发育稳定.
- Ubx基因在维持胸部细分身份和缓冲发育错误方面发挥着至关重要的作用.
- 这项研究提供了对Drosophila.在发育恒温的基因机制的洞察.
相关概念视频
Position-effect Variegation
In 1928, a German botanist Emil Heitz observed the moss nuclei with a DNA binding dye. He observed that while some chromatin regions decondense and spread out in the interphase nucleus, others do not. He termed them euchromatin and heterochromatin, respectively. He proposed that the heterochromatin regions reflect a functionally inactive state of the genome. It was later confirmed that heterochromatin is transcriptionally repressed, and euchromatin is transcriptionally active chromatin.
Background and Environment Affect Phenotype
Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
The Ratio of X Chromosome to Autosomes
In most organisms, sex is determined by the ratio of X and Y chromosomes. However, in some organisms, such as Drosophila and C.elegans, sex is determined by the ratio of the number of X chromosomes to the number of sets of autosomes. The Y chromosome in Drosophila is active but does not determine sex. It contains genes responsible for the production of sperms in adult flies.
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female Drosophila...
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female Drosophila...
Dosage Compensation
In animals, gender is determined by the number and type of sex chromosome. For example, human females have two X chromosomes, and males have one X and one Y chromosome, whereas C.elegans with one X chromosome is a male, and the one with two X chromosomes is a hermaphrodite.
In addition to sexual development, the X chromosome has genes involved in autosomal functions such as brain development and the immune system. Therefore, males and females with distinct numbers of X chromosomes will have...
In addition to sexual development, the X chromosome has genes involved in autosomal functions such as brain development and the immune system. Therefore, males and females with distinct numbers of X chromosomes will have...


