相关实验视频
在重症患者中预防压力. 解决不一致的元分析
D J Cook1, B K Reeve, G H Guyatt
1Department of Medicine, McMaster University Faculty of Health Sciences, Hamilton, Ontario, Canada.
JAMA
|January 24, 1996
概括
组胺2受体对抗剂显著降低了危急病患者的胃肠道出血. 糖酸盐在降低肺炎和死亡率方面表现有前途,为压力预防提供了潜在的替代方案.
科学领域:
- 关键护理医学 关键护理医学
- 药理学 药理学是指药理学的学科.
- 基于证据的医学基于证据的医学.
背景情况:
- 压力的预防对重症患者至关重要.
- 之前的系统性审查在有效性和安全性方面存在差异.
- 确定最佳的预防药物对于患者的治疗结果至关重要.
研究的目的:
- 解决先前系统概述中的差异.
- 估计压力预防对胃肠道出血,肺炎和死亡率的影响.
- 为了比较组胺2-受体对抗剂,抗酸剂和糖酸盐的疗效.
主要方法:
- 综合搜索已发表和未发表的研究.
- 在审查了269篇文章后,纳入了63项相关的随机对照试验.
- 独立评估研究质量,人群,干预和结果.
主要成果:
- 立体胺2-受体对抗剂显著减少了明显的和临床上重要的胃肠道出血.
- 与其他药物相比,苏克拉酸盐显示出较低的肺炎率和较低的死亡率的趋势.
- 之前审查中的差异源于研究选择,定义和统计方法.
结论:
- 立体胺2-受体对抗剂为减少临床重要胃肠道出血提供了有力的证据.
- 糖酸盐可能与胃pH值改变药物对出血一样有效,在肺炎和死亡率方面具有好处.
- 需要改进试验注册表和系统审查方法.
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